QuSome®

About QuSome®

About QuSome®

Achieving breakthrough effects in transdermal absorption
nanocapsule technology

In the past, great technology of liposomes has been used to enhance the transdermal absorption of drugs. The invention of this liposome has dramatically improved the effect of medicines.

Characteristics of liposome preparation

  1. While increasing the solubility of the poorly water-soluble active ingredients, it also increases the stability of the formulation itself and further increases the amount and speed at which the active ingredients reach the skin.
  2. Protects the active ingredient from the environment that influences stability such as extreme pH and oxidation.
  3. Structures of cell membranes and liposomes are very similar, the active ingredient can penetrate deep into the skin.
  4. It can be retained in the skin and increase the amount of active ingredient in the skin. This allows you to stay at the target site of the active ingredient for a long time, leading to higher pharmacological effects.

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Conventional Technology Issues

Conventional liposomes force high energy and form capsule structures (vesicles) using a mixer or sonication to form nanocapsule structures. However, during storage, the nanocapsule has a fatal problem of stability that is easy to break as it tries to return to a low energy stable state.

Another problem is that phospholipids are used to form nanocapsules. However, solvents may be used in the manufacturing process to dissolve the active ingredients in phospholipids, which is considered to be a safety issue.

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Birth of a New generation of DDS (Drug Delivery System)

By overcoming the biggest problems of liposome’s stability and safety concerns, and increasing the encapsulation rate of the active ingredient, QuSome® makes it possible to deliver more ingredients deep into the skin.

QuSome® has made it possible to overcome the problems of liposomes by inventing thermodynamically stable. A unique lipid different from the conventionally used phospholipids. These lipids are called DAG-PEG lipids (diacylglycerol-polyethylene glycol lipids).

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The difference between QuSome® and liposome

Parameter

Liposomes

QuSomes

Starting lipid

Phospholipids

DAG-PEG Lipids

Stability

Kinetic trap

Thermodynamically stable

Encapsulation

Good~55%

Excellent~90%

Drug Delivery

Excellent

Better

Scale-Up and manufacturing

Intensive and expensive

Simple

Cost

Expensive

1/10th the price

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Chemical difference between QuSome® and liposome

Chemical difference between QuSome® and liposome

The chemical difference between phosphatidylcholine (the molecule that forms liposome) and DAG-PEG (the molecule that forms QuSome®), lies at the end of the molecule. The phosphate group and choline are bonded to the end of phosphatidylcholine. Whereas the end of DAG-PEG lipids is bonded to PEG where some monomers are polymerized (see above).

Furthermore, DAG-PEG lipids can be diversified by changing the fatty acid chain length in the molecule and the degree of polymerization of PEG. However, only a few types of vesicles contain within.

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Thermodynamically stable QuSome®

QuSome® is formed spontaneously when a lipid with a specific molecular structure that is determined by the packing parameter (P) comes in contact with an antipodal environment such as water. With an average diameter of 100 nm and a dual membrane thickness of approximately 40 nm, this makes the vesicles thermodynamically stable.

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QuSome® encapsulation rate comparison

Capable of stably encapsulating more active ingredients

QuSome® encapsulation rate comparison

Liposome containing CoQ10 as the active ingredient and QuSome® nanocapsules were left at room temperature for 3 months, and their encapsulation rates were compared hourly. QuSome® has a higher encapsulation rate of CoQ10 at the start than liposomes, and retains that figure after 3 months.

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Release comparison of active ingredients

Deliver more active ingredients long time

Release comparison of active ingredients

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Benefits of implementation

Benefits of implementation

By encapsulating QuSome®, the active ingredient can reach the epidermis and dermis as well as the stratum corneum. The capsule is stored in the skin and remains effective for a long time by breaking the capsule and releasing the active ingredient little by little (storage effect). In addition, DAG-PEG lipid itself has the effect of improving the skin’s barrier function and moisturizing function.

The amount of active ingredient that gets into blood vessels is lower compared to liposomes, meaning that the toxicity is extremely low.

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Improve the effect